High Dose Thiamine (B1) in Parkinson's disease: An overview

This presentation gives an overview on High Dose Thiamine (B1) therapy in Parkinson’s Disease and explains why this therapy holds a high potential as an intervention to modify the course of Parkinson’s disease. It goes through Dr Costantini’s research work, ending with the plan to confirm his preliminary findings through a Randomized Controlled Trial (RCT).

The B1 protocol (High Dose Thiamine) in Parkinson's disease: review of six forms of magnesium supplements

This presentation provides flash cards in an animated form on six forms of magnesium (Mg) supplements, namely Mg-l-threonate, Mg citrate, Mg glycinate, Mg malate, Mg oxide and Mg sulfate, with the conclusions of on each of them. The information is taken from a detailed review on Mg presented in the document "Thiamine and magnesium" prepared by and available in the website area reserved for medical professionals. Together with thiamine (B1) and B-complex, magnesium represents one of the three key elements of the B1 therapy in Parkinson's.

Parkinson's B1 Therapy (HDT) Protocol: Why magnesium?

This presentation describes the rationale for magnesium supplements in B1 therapy in Parkinson's disease. Magnesium, together with thiamine (B1) and B vitamins, is one of the three elements of the B1 Protocol. Magnesium deficiency is very common in the population in general and in Parkinson's disease in particular. The presentation reviews risk factors for, and screening for, magnesium deficiency, interactions of magnesium with other medicines and some of the forms of magnesium supplements currently available. Mention is made of the effects of magnesium deficiency, if left undiagnosed and untreated. The presentation is based on a detailed review on magnesium in "Thiamine and magnesium" prepared by and available in the website area reserved for medical professionals at

Screening tool for vitamin B12 deficiency in Parkinson's B1 therapy

This presentation proposes a screening tool to identify People with Parkinson's who have vitamin B12 deficiency. Vitamin B12 deficiency is an important condition which needs to be recognised and treated promptly as it may result in permanent neurological damages. Many of the clinical signs of vitamin B12 deficiency are aspecific and are the same as those of Parkinson's. This may challenge the diagnosis and leave many PwP undiagnosed and untreated. Vitamin B12 deficiency is common in Parkinson's disease. It is important to identify those PwP most at risk of vitamin B12 deficiency also before starting thiamine, so as to correctly attribute any change in symptoms following vitamin B1 supplementation to thiamine, without the potential interference of vitamin B12 deficiency. The presentation is based on a document prepared by which reviews the most common risk factors for vitamin B12 deficiency in Parkinson's disease as the basis for the screening tool. The document is available in the website area reserved for medical professionals at

How to enter symptom data in a spreadsheet programme and generate charts to monitor B1 therapy

This brief tutorial shows how to enter data in an Excel spreadsheet developed to monitor symptoms when searching the right dose of vitamin B1, according to the High Dose Thiamine (HDT) protocol for Parkinson's
( download the spreadsheet ).
Charts, one for each symptom, are automatically generated by the programme, showing trends over time. In this way, it's easier to see symptom response to different doses of vitamin B1.

How to create a spreadsheet programme from scratch and generate charts to monitor B1 therapy

This tutorial guides you through the key steps to develop a spreadsheet from scratch to monitor symptoms in vitamin B1 therapy for Parkinson's, automatically generating charts for each symptom upon entering symptom scores. Charts are a very effective way to display symptom trends. Our efforts are specifically aiming at PwP's challenging task of finding the right dose and keeping record of all symptoms, of any trial by vitamin B1 dose and of trends of symptom response to different doses of vitamin B1. When going through the trial and error phase to find the right dose of vitamin B1 (thiamine), it is important to detect not only any improvement in any symptom but also to see whether this is followed by any worsening of any symptom or by the appearance of any new symptom (overdose). This is the second tutorial to make available a simple and intuitive Excel sheet layout for those who want to build it from scratch. An advantage of the spreadsheet compared with existing app is that one has the additional option to play with the data as much as s/he wants, to look at whatever monitoring aspects s/he wants to at any time. The dataset is there and can be used in any possible way, in addition to what is generated automatically by the programme. One can go back at any time to the monitoring data entered earlier to see how symptoms responded to different doses at different times and plot into graphs also several symptoms and vitamin b1 doses at the same time. The idea is to offer an additional means of monitoring symptoms and overall trends, with a special focus on finding the right dose.

Text author: Sergio Pièche
Page updated - 16/10/23