Fundraising for an AI‑Powered Q&A Platform on the B1 Protocol in Parkinson’s
20 April 2026: UPDATE — The Beta Version Is Live!
The beta version of the AI‑powered Q&A Platform on the B1 protocol is now available in English and Italian, with more languages currently being tested.
You can start asking your questions right away — simply click the blue icon at the bottom right of the page.
Access is free, thanks to our donors. No registration is required.
This tool expands our educational ecosystem — alongside Daphne Bryan’s book, our website, YouTube channel, and Facebook community — and reinforces our commitment to accessibility, clarity, and patient empowerment.
If you’d like to help us refine the tool, add new features, and expand it to more languages so it can reach people worldwide, please consider supporting the project.
The Initiative On 12 March 2025, we launched an ambitious project—and a fundraising campaign—to build a multilingual, AI‑powered Question & Answer platform dedicated to the B1 protocol in Parkinson’s.
The Need For people living with Parkinson’s—and their caregivers—the B1 protocol can feel overwhelming. Many don’t know where to begin, and even healthcare providers often struggle to answer patients’ questions. Clear, reliable, and accessible guidance is essential: good knowledge of the protocol increases the chances of implementing it correctly and setting realistic expectations about its possible effects.
Today, volunteers like Daphne Bryan (author of Parkinson’s and B1 Therapy), Sergio Pièche (President of the nonprofit B1 Parkinson’s Association), and others dedicate countless hours answering questions online. But demand is growing, and many questions repeat.
The Answer That’s why we have built an AI‑powered Q&A platform that:
Provides instant, reliable answers to common questions
Frees up experts to focus on complex, personalized support
Expands access to trusted information for patients and professionals
Ensures 24/7 availability across languages and regions
What It Does This tool empowers thousands of families and healthcare providers worldwide, giving them confidence and clarity in navigating B1 therapy.
We believe that knowledge is power—and technology can deliver it.
Progress So Far Your generosity has so far supported:
The development of a free, first version of a user‑friendly AI digital platform on the B1 protocol accessible worldwide from this website
The translation of scientific knowledge into practical, everyday guidance.
What’s Next — With Your Help We are now working on:
Improving accuracy and depth of answers
Adding more languages
Enhancing the interface and accessibility
Integrating feedback from patients, caregivers, and professionals
With your help, the tool will empower patients, caregivers, and healthcare providers—delivering hope, clarity, and support at the click of a button.
Join Us Parkinson’s is a complex condition. Navigating it shouldn’t be.
How to Donate We’ve created a dedicated GoFundMe page to support this project:
A fund-raising drive is ongoing to finance a randomized, double-blind, placebo-controlled trial (RCT) to determine the safety and dose-dependent efficacy of high-dose thiamine (B1) in Parkinson’s Disease.
RCTs are currently considered the gold standard in research in the medical field.
The RCT will provide the evidence on the effectiveness of the HDT (B1) therapy protocol that the international health community is waiting for, to make it acceptable to the scientific community and available to the millions of People with Parkinson’s Disease.
More information on the methodology and other details on the RCT is available in the Research pages of this website.
The HDT Foundation is responsible for this campaign. Marco Colangeli, formerly Dr Costantini’s assistant for the HDT protocol, is the HDT focal point for this purpose. Fund-raising requires the contribution of donors and possibly charity and philanthropy foundations.
Ms Daphne Bryan, author of the book on “Parkinson’s and the B1 therapy”, has very generously donated 100% of her book sales proceeds to this campaign.