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Fundraising for an AI‑Powered Q&A Platform on the B1 Protocol in Parkinson’s
The Initiative
On 12 March 2025, we launched an ambitious project—and a fundraising campaign—to build a multilingual, AI‑powered Question & Answer platform dedicated to the B1 protocol in Parkinson’s.
The Need
For people living with Parkinson’s—and their caregivers—the B1 protocol can feel overwhelming. Many don’t know where to begin, and even healthcare providers often struggle to answer patients’ questions. Clear, reliable, and accessible guidance is essential: good knowledge of the protocol increases the chances of implementing it correctly and setting realistic expectations about its possible effects.
Today, volunteers like Daphne Bryan (author of Parkinson’s and B1 Therapy), Sergio Pieche (President of the nonprofit B1 Parkinson’s Association), and others dedicate countless hours answering questions online. But demand is growing, and many questions repeat.
The Answer
That’s why we are building an AI‑powered Q&A platform that will:
This tool will empower thousands of families and healthcare providers worldwide, giving them confidence and clarity in navigating B1 therapy.
We believe that knowledge is power—and technology can deliver it.
What Your Donation Supports
Your generosity will directly fund:
Since launch, we’ve already achieved:
A first version is already in testing. We’re close to sharing it with you—free of charge—for wider testing. But we need your support to cover final development costs, including expert technical contributions to refine the system and make it accessible through multiple platforms and a dedicated app.
With your help, we can build a tool that empowers patients, caregivers, and healthcare providers—delivering hope, clarity, and support at the click of a button.
Join Us
Parkinson’s is a complex condition. Navigating it shouldn’t be.
How to Donate
We’ve created a dedicated GoFundMe page to support this project:
👉Donate here or click the button below.
Funds go directly to the B1 Parkinson’s Association, which is fully involved in this initiative.
Together, let’s turn knowledge into empowerment.
The Initiative
On 12 March 2025, we launched an ambitious project—and a fundraising campaign—to build a multilingual, AI‑powered Question & Answer platform dedicated to the B1 protocol in Parkinson’s.
The Need
For people living with Parkinson’s—and their caregivers—the B1 protocol can feel overwhelming. Many don’t know where to begin, and even healthcare providers often struggle to answer patients’ questions. Clear, reliable, and accessible guidance is essential: good knowledge of the protocol increases the chances of implementing it correctly and setting realistic expectations about its possible effects.
Today, volunteers like Daphne Bryan (author of Parkinson’s and B1 Therapy), Sergio Pieche (President of the nonprofit B1 Parkinson’s Association), and others dedicate countless hours answering questions online. But demand is growing, and many questions repeat.
The Answer
That’s why we are building an AI‑powered Q&A platform that will:
- Provide instant, reliable answers to common questions
- Free up experts to focus on complex, personalized support
- Expand access to trusted information for patients and professionals
- Ensure 24/7 availability across languages and regions
This tool will empower thousands of families and healthcare providers worldwide, giving them confidence and clarity in navigating B1 therapy.
We believe that knowledge is power—and technology can deliver it.
What Your Donation Supports
Your generosity will directly fund:
- Development and training of the AI system on the B1 protocol
- Building a user‑friendly digital platform accessible worldwide
- Collaborations to ensure accuracy
- Translating scientific knowledge into practical, everyday guidance
Since launch, we’ve already achieved:
- Uploaded over 200 carefully selected references to the AI platform
- Developed 130 core questions, expanded to over 600 Q&A pairs
- Conducted internal testing to improve accuracy and usability
A first version is already in testing. We’re close to sharing it with you—free of charge—for wider testing. But we need your support to cover final development costs, including expert technical contributions to refine the system and make it accessible through multiple platforms and a dedicated app.
With your help, we can build a tool that empowers patients, caregivers, and healthcare providers—delivering hope, clarity, and support at the click of a button.
Join Us
Parkinson’s is a complex condition. Navigating it shouldn’t be.
How to Donate
We’ve created a dedicated GoFundMe page to support this project:
👉Donate here or click the button below.
Funds go directly to the B1 Parkinson’s Association, which is fully involved in this initiative.
Together, let’s turn knowledge into empowerment.
A fund-raising drive is ongoing to finance a randomized, double-blind, placebo-controlled trial (RCT) to determine the safety and dose-dependent efficacy of high-dose thiamine (B1) in Parkinson’s Disease.
RCTs are currently considered the gold standard in research in the medical field.
The RCT will provide the evidence on the effectiveness of the HDT (B1) therapy protocol that the international health community is waiting for, to make it acceptable to the scientific community and available to the millions of People with Parkinson’s Disease.
More information on the methodology and other details on the RCT is available in the Research pages of this website.
RCTs are currently considered the gold standard in research in the medical field.
The RCT will provide the evidence on the effectiveness of the HDT (B1) therapy protocol that the international health community is waiting for, to make it acceptable to the scientific community and available to the millions of People with Parkinson’s Disease.
More information on the methodology and other details on the RCT is available in the Research pages of this website.
The HDT Foundation is responsible for this campaign. Marco Colangeli, formerly Dr Costantini’s assistant for the HDT protocol, is the HDT focal point for this purpose. Fund-raising requires the contribution of donors and possibly charity and philanthropy foundations.
Ms Daphne Bryan, author of the book on “Parkinson’s and the B1 therapy”, has very generously donates 100% of her book sales proceeds to this campaign.
To donate, go to the https://www.gofundme.com/f/high-dose-thiamine-protocol
or click the button below.
Every contribution is valued and really does help. Please give what you can - thank you.
Ms Daphne Bryan, author of the book on “Parkinson’s and the B1 therapy”, has very generously donates 100% of her book sales proceeds to this campaign.
To donate, go to the https://www.gofundme.com/f/high-dose-thiamine-protocol
or click the button below.
Every contribution is valued and really does help. Please give what you can - thank you.
Text author: Sergio Pièche
Page updated - 17/12/25
Page updated - 17/12/25